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Curaleaf

Curaleaf

Curaleaf

Curaleaf is a vertically integrated, multi-state cannabis company operating cultivation, manufacturing, and retail assets across 18 regulated U.S. markets, supporting medical and adult-use consumers through a broad branded product portfolio.

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Curaleaf Holdings, Inc. is a vertically integrated cannabis company headquartered in Stamford, Connecticut, and publicly traded on the Canadian Securities Exchange. Founded in 2010 as PalliaTech, the company rebranded to Curaleaf in 2018 and has since expanded to operate dispensaries across 18 U.S. states, serving both medical patients and adult-use consumers.

Led by CEO Boris Jordan, Curaleaf operates cultivation facilities, processing sites, and retail locations throughout the country, enabling the company to control quality from seed to sale. The company’s brand portfolio includes Select, known for premium cannabis oil vapes and cartridges; Grassroots, which offers flower and concentrates; Anthem, a classic pre-roll brand celebrating American-grown cannabis; Find, an affordable flower line; JAMS, a flavor-forward edibles brand; Reef, featuring flower products; and B Noble, a social equity-focused brand founded by Hip-Hop pioneer Fab 5 Freddy.

Through strategic acquisitions—including Select in 2019 and Grassroots Cannabis in 2020—Curaleaf has built a comprehensive product lineup spanning flower, vapes, pre-rolls, edibles, and concentrates. The company continues expanding its retail footprint and brand offerings, positioning itself as a major player in the evolving U.S. cannabis market.

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Business of Cannabis research roundup

Latest Studies Map Cannabis Efficacy Across Pain, Migraine, and Autism Applications

Latest Studies Map Cannabis Efficacy Across Pain, Migraine, and Autism Applications

Welcome to Business of Cannabis’ new research digest, unpacking the latest clinical evidence shaping cannabis therapeutics.

While headlines often focus on regulatory shifts and market access, the scientific foundation underpinning medical cannabis continues to evolve at a pace, yet rigorous clinical trial data rarely receive the attention it deserves outside academic circles.

With optimism that the US could reschedule cannabis in the coming months, cannabis research could see a wave of investment flood through the research sector, having major implications for its integration into mainstream healthcare. 

Beyond the Abstract aims to cut through PR-hype and methodological complexity to deliver a clear-eyed analysis of emerging research, from pain management and neurological conditions to rare disease applications. We’ll examine what the data actually shows, where evidence gaps remain, and how new findings might influence clinical practice and regulatory frameworks across Europe and beyond.

This edition launches with three landmark studies published in recent months: a major systematic review on cannabis for chronic pain, the first randomised controlled trial of vaporised cannabis for acute migraine, and new data on CBD-rich formulations for ADHD symptoms in children with autism spectrum disorder.

For comprehensive access to the latest cannabis clinical trials across chronic pain, epilepsy, oncology, and other therapeutic areas, explore Business of Cannabis’ Cannabis Research Repository, a continuously updated database of human studies, systematic reviews, and real-world evidence.

Cannabis for chronic pain comparable to opioids

A comprehensive systematic review from Oregon Health & Science University has quantified cannabis efficacy for chronic pain, revealing stark differences between THC and CBD-dominant products.

The study, ‘Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain: 2025 Update’, marked the fourth and final annual update of the ‘living review’, which continually adapted to ‘identify and synthesise’ new literature as it was published. 

It analysed 25 randomised controlled trials (RCTs) involving 2,303 patients, predominantly those with neuropathic pain, finding that high-THC products reduced pain severity by 0.78 points on a 10-point scale compared to placebo. Products with comparable THC-to-CBD ratios performed slightly worse, showing reductions of 0.54 points.

Despite both being THC-based pharmaceuticals, Nabilone demonstrated moderate pain reduction of 1.59 points on a 0-10 scale, while Dronabinol showed minimal effect at just 0.23 points, a statistically significant difference. 

Across four RCTs involving 334 patients, synthetic or purified CBD alone was ‘not associated with decreased pain intensity’ versus placebo, with the pooled mean difference actually favouring placebo by 0.40 points (95% CI −0.14 to 1.00). CBD also showed no benefit in terms of function or pain response rates.

Nabiximols (Sativex), and oromucosal spray containing 2.7mg THC and 2.5mg CBD per spray, showed pain reduction of 0.54 points and functional improvement of 0.42 points, both ‘just below the threshold for a small effect’ according to the review’s criteria.

High-THC products carried substantial risks, as evidenced by dizziness in 33% of cases versus 15% with the placebo (relative risk [RR] 2.20), sedation in 24% vs. 16% (RR 1.50), and withdrawal due to adverse events in 14% vs. 7% (RR 1.92).

All 25 trials were short-term only (1-6 months), predominantly enrolled neuropathic pain patients (64%), with mean age 53 years. The review found ‘insufficient evidence’ on cannabis use disorder development, long-term outcomes, or effects beyond neuropathic pain.

The review notes that cannabis products’ pain reduction appears ‘comparable to those observed with prescription opioids, several nonopioid medications, and nonpharmacological interventions,’ though the authors emphasise this cross-trial comparison ‘must be done with extreme caution’ and head-to-head trials are needed.



First RCT shows CBD & THC combination beats placebo for acute migraine

The first randomised, double-blind, placebo-controlled trial of cannabis for acute migraine has demonstrated that vaporised THC combined with CBD outperforms placebo, but in similar findings to the systematic review above, CBD alone shows little benefit.

University of California San Diego researchers enrolled 92 participants who treated 247 migraine attacks with four different vaporised cannabis treatments in randomised order: 6% THC, 11% CBD, 6% THC plus 11% CBD, or placebo.

The THC+CBD combination achieved the primary outcome of 2-hour pain relief in 67% versus 47% with placebo (OR 2.85, p=0.016). Critically, it also met secondary endpoints of pain freedom (35% vs 16%, p=0.017) and most bothersome symptom freedom (60% vs 35%, p=0.005), benefits that persisted at 24 and 48 hours.

THC alone achieved pain relief (69% vs 47%, p=0.008) but failed to reach statistical significance for pain freedom or symptom relief at two hours and showed no sustained benefits. CBD alone demonstrated no superiority to placebo on any measure.

The combination reduced photophobia and phonophobia but not nausea, confirming ‘antimigraine effects rather than THC’s established antiemetic effects.’ Mean subjective highness was lower with THC+CBD (2.4/10) than THC alone (3.5/10), consistent with CBD’s role as a negative allosteric modulator of CB1 receptors.

Researchers noted critical limitations, including single-dose testing (no data on medication overuse headache or cannabis use disorder with repeated use), NIDA cannabis devoid of terpenes and minor cannabinoids, and pain relief rather than pain freedom as the primary endpoint, contrary to current International Headache Society guidelines

CBD-rich cannabis shows behavioural improvement in children with ADHD and ASD

 

An open-label study from Tel Aviv University has reported behavioural improvements in children with autism and ADHD following CBD-rich cannabis treatment, though the lack of placebo control limits conclusions about causation.

Researchers evaluated 53 children and young adults using the Conners’ Teacher Rating Scale before and after 3-6 months of CBD-rich cannabis oil. Teachers reported statistically significant improvements in anxious-shyness, perfectionism, ADHD index scores, emotional lability, and hyperactive-impulsivity.

Blood analysis revealed no consistent relationship between CBD concentrations and most behavioural changes, except for emotional regulation. Higher CBD levels correlated with greater improvements in emotional lability, suggesting a possible dose-response effect.

The study represents ‘the first prospective study to evaluate the effects of CBD-rich cannabis on ADHD symptoms in children with ASD using standardised teacher-based assessments,’ addressing concerns that parent-reported outcomes may be influenced by expectation bias.

However, the open-label design, where all participants knew they were receiving active treatment, substantially limits interpretation. Authors acknowledge this ‘limits the ability to draw firm conclusions about causation’ and emphasise ‘the need for randomised, controlled trials to confirm efficacy.’

A separate 2025 UC San Diego placebo-controlled trial testing purified CBD (Epidiolex) up to 20mg/kg/day in autistic boys found no significant difference between CBD and placebo groups on behavioural measures, with both groups improving equally, suggesting open-label improvements may reflect placebo effects, natural symptom variation, or regression to the mean rather than pharmacological action

The post Latest Studies Map Cannabis Efficacy Across Pain, Migraine, and Autism Applications appeared first on Business of Cannabis.

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Hyper Cherry Haze Feminized Seeds

Hyper Cherry Haze Feminized Seeds

Hyper Cherry Haze Feminized Seeds

Description

When you first see Hyper Cherry Haze, the Gelato influence is hard to miss. These buds are thick and often show off their deep purple colors hidden under a heavy layer of frosty trichomes. The smell is just as impressive as the look. It hits you with a sharp mix of zesty citrus and earthy tones, followed by a sweet, creamy finish that lingers on your tongue. Some smokers also pick up a bit of diesel and chemical notes, which adds a nice edge to the fruity profile.

The experience starts almost instantly with a bright, cerebral buzz. You will likely feel a surge of creative energy and focus, making it a great companion for artistic projects or morning routines. While your mind is racing with happy thoughts, a soothing physical wave from the Gelato side keeps you grounded. It never feels too heavy or sleepy, so you can stay productive while enjoying a deep sense of euphoria. It is truly an all-day smoke for those who want to stay active and stress-free.

The post Hyper Cherry Haze Feminized Seeds appeared first on Crop King Seeds.

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What to Consider When Looking for a Cannabis Dispensary in Los Angeles

What to Consider When Looking for a Cannabis Dispensary in Los Angeles


The cannabis industry in Los Angeles has grown exponentially over the past decade, offering residents and visitors an incredible variety of dispensaries to choose from. Whether you’re seeking relief from chronic pain, managing stress, or simply exploring recreational options, finding the right cannabis dispensary is essential. But with so many locations scattered across the city, […]

The post What to Consider When Looking for a Cannabis Dispensary in Los Angeles appeared first on Stoner | Pictures | Stoners Clothing | Blog | StonerDays.



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Insurance Has Become a Critical Benchmark for Cannabis Industry Maturity

Insurance Has Become a Critical Benchmark for Cannabis Industry Maturity

Insurance Has Become a Critical Benchmark for Cannabis Industry Maturity

Since the emergence of the legal cannabis industry across the Western world, operators have persistently been forced to deal with an issue faced by few counterparts in established sectors: they can’t get insured. 

In the UK, we’ve reported on firms seeing their bank accounts closed overnight with no explanation, facing rejections for even basic employer liability coverage, and facing fines of up to £2500 a day for operating without protection. 

Similar stories extend throughout Europe, while US operators facing ongoing federal prohibition remain exposed to risks every other sector can easily insure against, such as product liability, theft, crop failure, and workplace injuries.

According to Claire Davey, Senior Vice President of Product Innovation and Emerging Risk at Relm, whose team co-authored a new Risk Briefing on the cannabis sector with Prohibition Partners, this dynamic is now beginning to change. 

“Compared to Europe, the US and Canadian insurance market has facilitated greater access to insurance for operators, during the last 2-3 years, particularly for relatively commonplace (yet necessary) coverages, such as Directors and Officers Liability, due to relative market maturity,” she told Business of Cannabis. 

Despite improvements, cannabis remains a notable outlier in terms of access to insurance coverage. According to the recently published report, however, insurance challenges are now less about whether insurance capital is available but more about whether operators are professionalised enough to secure it. 

Join Relm and Prohibition Partners on Wednesday, February 04, at 3pm, for a live webinar unpacking the key findings from the Risk Briefing: Cannabis 2026 report.

The session will explore where risk concentrations are highest across the cannabis supply chain, why contamination continues to drive recalls, and what leading operators are doing to strengthen governance and reduce exposure.

What underwriters actually demand

According to Davey, the barriers to comprehensive coverage are twofold. “With respect to the US, it is regulatory uncertainty and the lack of governance around particular risk exposures. 

“Insurers are highly regulated businesses, and they often need greater certainty regarding legality. They also want to be clear on how insureds are managing their risk.”

For European and international markets, ‘the regulatory concern is paired with the lack of size and maturity of the cannabis industry, which has not yet reached enough of  a critical mass to convince insurers of committing to the opportunity.’

The Relm Risk Briefing, which draws on interviews with leading operators like Glass Pharms, Linnea, SOMAÍ Pharmaceuticals, and PHCANN International, explores the dramatic variations in what underwriters look for depending on coverage type. 

Product Liability insurers are ‘keen to see internationally recognised quality assurance certifications that are achieved and maintained’. In practice, this means EU-GMP certification is critical, given that few jurisdictions offer full alignment with Good Manufacturing Practice standards, and contamination risks persist throughout the supply chain.

For Crime insurance covering theft of crops and assets, ‘insurers are looking to see that a range of physical, logical and technical controls are implemented.’ Between 2018 and 2022, Canadian licensed producers reported over 2200 kg of cannabis as missing or stolen, with most incidents during transportation.

Meanwhile, for D&O (Directors and Officers) coverage, the focus shifts to governance fundamentals. “What do their financials show? How is the business managing regulatory risk? What are they communicating to investors and how are they delivering on this?” 

This scrutiny reflects genuine exposure. Canopy Growth Corp., one of the largest publicly traded cannabis companies, currently faces a class action lawsuit alleging misleading statements about production costs.

Insurance as driver, not just an indicator

Davey argues that the relationship between insurance and operational excellence extends beyond simple risk transfer, with the process of applying for insurance ‘encouraging a business to reflect on, and provide evidence of, its governance practices and risk reduction strategies’. 

“If the application for insurance suggests that risk posture is weak, or it is lacking data transparency, the operator needs to improve this in order to avoid the withdrawal of insurance coverage or the increased premiums and retentions that may result from poor risk management. Thus, insurers are often pushing for best practices, and encouraging and rewarding such improved postures.”

The report’s risk mitigation strategies span the entire supply chain. In cultivation, controlled environments, tissue culture, genetics for consistency, and integrated pest management demonstrate operational maturity that insurers reward. 

Glass Pharms CEO James Duckenfield notes: “Seeds proved too variable, so we use only tissue culture genetics for consistency.”

In manufacturing, where, for example, a January 2025 explosion at PharmaCann’s Maryland extraction facility caused over $250,000 in damages, insurers demand strict safety protocols and facility controls. 

For distribution, where temperature excursions threaten product integrity, operators need GDP-aligned transport with data loggers and comprehensive cargo insurance. Linnea CEO Susanne Caspar said: “We always advise clients to have door-to-door coverage, regardless of Incoterms, to avoid disputes between buyers and sellers.”

Inadequate coverage and its costs

The report also explores incidents illustrating the financial consequences of inadequate risk management and insurance.

River Valley Growers in Massachusetts lost its entire 2022 harvest, valued at $7 million, when pesticide drift from a neighbouring farm contaminated their crop. The cultivator went out of business, unable to meet production contracts. 

C&C Manufacturing LLC in Missouri had its license revoked after creating a distillate with unregulated THC levels, triggering a statewide recall of 135,000 products in 2024. 

Elsewhere, NNK Equity LLC in New Mexico faced seizure and destruction of tens of thousands of plants worth hundreds of thousands of dollars after failing multiple compliance requirements, including inadequate security and track-and-trace violations.

These incidents illustrate that operators who treat insurance as an administrative burden rather than good risk management discipline leave themselves exposed not just to claim denials but to the underlying operational failures that trigger claims.

The European opportunity

While North American markets face saturation and regulatory uncertainty, Europe presents a different trajectory. “We would expect that there will be an expansion of insurance capacity for the European cannabis markets over the coming years,” Davey suggests. 

“The US and Canada are already relatively saturated, although the US’s move towards rescheduling may make this even more prominent. The respective European approaches to deregulation—which are quite steady and measured—offer a greater degree of certainty and confidence that enable insurers to plan for, and mobilise over the medium to longer term.”

Europe’s total cannabis sales are forecast to grow from $1.5 billion in 2025 to $3.3 billion by 2030, driven by permanent frameworks in Denmark and France, market expansion in the UK and Germany, and broader adoption. The pharmaceutical focus, emphasising GMP facilities, pharmacy distribution, and prescription-based access, provides the regulatory clarity insurers need.

Germany offers public health insurance reimbursement, a stability factor appealing to underwriters. France’s transition from pilot program to generalised medical access in April 2026 represents the measured regulatory evolution. Spain, Slovenia, Ukraine, and Bosnia and Herzegovina are developing frameworks prioritising pharmaceutical standards over rapid commercialisation, a pace that may frustrate operators but reassures insurers.

“The next phase of cannabis growth will belong to operators that act first to manage risk. Those who build insured, transparent operations now will define standards, secure capital, and outpace slower competitors,” the report notes. 

The capital markets dimension amplifies this dynamic. Investors and lenders increasingly require comprehensive insurance as a financing condition. A cannabis operator seeking growth capital must demonstrate not just that it has insurance, but that its risk posture is strong enough to maintain coverage through scaling and market expansion.

“The Risk Briefing provides great insights into the different risk mitigation best practices that operators can implement in order to shift the needle in the underwriting process,” Davey continued. 

The operators featured in the report demonstrate these principles. PHCANN International’s Macedonian facility employs 5-meter walls, licensed armed guards, over 200 cameras, and annual attack-response drills, with special forces response available within one minute. Linnea holds an EcoVadis silver medal, placing it among the top 15% of assessed companies worldwide on ESG criteria, monitoring emissions and recycling extraction waste into renewable energy.

SOMAÍ Pharmaceuticals emphasises supplier financial viability: “Companies in financial trouble often cut corners, even unintentionally. We’re always transparent about our own financials with partners,” says CEO Michael Sassano.


 

As insurance capacity expands in select markets, underwriters now have enough data to differentiate between well-managed and poorly-managed operators. Premium spreads will widen. Coverage restrictions will become more tailored. Operators with robust risk management will access broader coverage at lower cost, while those with weak governance will find themselves increasingly uninsurable.

The word ‘cannabis’ once all but guaranteed rejection. Today, proving professionalism has become the requirement for protection.

The Risk Briefing: Cannabis 2026 is available from Relm Insurance and Prohibition Partners.

The post Insurance Has Become a Critical Benchmark for Cannabis Industry Maturity appeared first on Business of Cannabis.

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